OraWax™, Arcato’s lead product, is a patented time-release formulation combining wax, benzocaine, and special polymers. Patients who apply this medicated wax to their orthodontic brackets experience relief from discomfort by reduction of friction between the bracket and the mouth, and by the sustained release of benzocaine from the wax matrix. In a clinical trial conducted at the University of Kentucky dental school, in patients who were being fitted with braces for the first time, OraWax™ was compared to regular (unmedicated) orthodontic wax. A highly significant difference in the level of pain was observed between patients using OraWax™ and patients using the regular wax. In fact, patients using OraWax™ experienced a four-fold decrease in reported pain, and relief was seen as early as one hour after administration. The results of this study were published in the American Journal of Orthodontics and Dentofacial Orthopedics.